The Kümmerli lab at the Department of Quantitative Biomedicine is looking for a master student to carry out their thesis project. The project is titled “Experimental evolution of clinical Pseudomonas aeruginosa isolates in fluctuating antibiotic conditions”. The project will involve running experimental evolution with clinical isolates of Pseudomonas aeruginosa (PA) from patients with burn wounds, as well as laboratory mutants of PA. PA is a pathogen of considerable interest as it causes life threatening infections and boasts a diverse repertoire of antibiotic resistance mechanisms. These mechanisms, coupled with inherent phenotypic plasticity, allow PA to cause both chronic and acute infections. This project will involve microbiology, evolutionary biology, molecular biology, high-throughput screening, and sequencing. Interested applicants can write to: [email protected] for more information.
Starting date: Summer 2024 or upon arrangement. Duration: 12 months
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We've uploaded a fresh batch of preprints!
1. Impact of biotic and abiotic factors on competitive interactions between Pseudomonas aeruginosa and Staphylococcus aureus 2. Predicting bacterial interaction outcomes from monoculture growth and supernatant assays 3. Space and epigenetic inheritance determine inter-individual differences in siderophore gene expression in bacterial colonies 4. A green-fluorescent siderophore protects bacterial communities from UV damage We are pleased to announce the publication of our latest research paper, in which we show the evolution of resistance in S. aureus against inhibitory molecules secreted by P. aeruginosa.
We have a new paper in Proceedings of the Royal Society B!
This work was led by Désirée Schmitz, and examines the ecological dynamics between pathogens and how they affect virulence and host survival. In collaboration with the Bigler lab and our colleagues from Nanjing Agricultural University, we have published a new paper in Metallomics. Congratulations to everyone involved.
We just released a new preprint on competition sensing by P. aeruginosa.
Two new master students joined our lab at the beginning of this year.
Serena Provveduto will work with pathogens isolated from the lungs of children suffering from cystic fibrosis to investigate the evolution of antibiotic resistance. Joel Frommenwiler will focus on antibiotic resistance or virulence factors in bacterial strains present in clinical samples from burn wounds. Welcome to the team. Rolf's review article on mechanisms, ecology, and evolution of Iron acquisition strategies in pseudomonads was published in Biometals.
Priya's excellent work on quorum-sensing activation and coordination in Pseudomonas aeruginosa got published in Current Biology. Congratulations!
We have recently welcomed three new PhD students in our lab.
Daniela Rovito will investigate social interactions between ESKAPE pathogens, using both in-vivo and in vitro models, and how they could be exploited to help treat infections. Simon Maréchal will work with bacterial communities isolated from the environment to explore the traits that determine community assembly and stability. Sukrit Suresh will employ experimental evolution to elucidate interaction between pathogens over evolutionary time and under different stressful conditions. |
AuthorRolf Kümmerli Archives
February 2024
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